Herbal Remedies for Cancer Patients

Placenta, Childbirth, Adhesive placenta, Placenta Accreta Spectrum,Hyper-invasive placental cell

A recent study led by researchers at the University of California in Los Angeles (UCLA) showed new details about the causes of the adhesive placenta that occurs when the placenta does not break apart from the womb during childbirth, posing a significant risk to the mother and the baby.

 What's the placenta stuck in?

 Placenta Accreta Spectrum is a serious condition in which placenta is not naturally separated during childbirth, causing severe bleeding and threatening the lives of both the mother and the child.

Attention to the causes of this situation has been deepened by the recent increase in infection rates in recent decades, estimated at 1 per 272 births in the United States of America, compared with 1 per 30,000 births in the 1960s, i.e., the number of cases has increased by about 110 more times today!

 The old look

 The main cause of the conjoined placenta is yet to be determined, although it is more common in women who have undergone Caesarean sections.

One of the assumptions that was prevalent among scientists is that a type of hyper-invasive placental cell called "aeroblast cells" or "Trophoblasts," is responsible for the penetration and adhesion of placental cells in the uterus.

But instead of blaming only the tumor cells, the study revealed that genetic and cell changes in the cells that connect the uterus to the placenta may have a role in the injury.

 Recent genetic discoveries.

 Dr. Yilda Avchar, a maternal and fetus medical specialist at the David Gavin School of Medicine at the University of California in Los Angeles (UCLA), led this research by using two new techniques to analyse individual cells at the placental and uterine levels, and to create an integrated vision of the causes of the conjoined placental, and its impact on the health of the mother and the newborn.
This work revealed a variety of genes expressed differently in the case of the adhesive placenta, which, according to shared Dr. Deborah Krakow, head of the Women ' s and Obstetrics Department of the David Gavin School of Medicine at the University of California in Los Angeles, allowed the placenta to stick more strongly in the womb.

 Changes in communication signals between the uterus and the placenta

Research has also found that in the case of a conjoined placenta, the layer of uterine lining formed during pregnancy, and the blood vessels associated with it, sends different signals to the placenta, making it firmly attached to the belly of the uterus, not naturally separated at birth, which leads to many serious complications.

 Details of the study

The research team took 12 samples for study, 6 of which were natural, 6 were for adhesive placental disturbance, genetic analyses of approximately 31,406 individual cells were performed, and an integrated genetic map was created to understand more about the causes of this situation, how it was accurately discovered, and how successful remedies were found.

Trophoblasts, Genetic changes, Uterus, Blood vessels, Genetic analysis

Authors of the study

 In addition to Dr. Yelda Afshar and Dr. Deborah Krako, the co-authors of UCLA University include:

• Dr. Ophelia yen.

• Guadalupe Martinez.

• Dr. Viang Ma.

• Dr. Pharmacist Christine Jang.

• Dr. Hesyan-Rong Tsing.

• Dr. Yazhin Zhou.

• Dr. Yin.

Co-authors of the Cedars-Senay Medical Center:

• Dr. Jenna Kim.

• Dr. Song Young Yoo.

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